HRID1409934

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID136759

cis-4-tert-Butylcyclohexane carboxylic acid

C11H20O2

结构：Cl.Cl.N[C@H]1CC[C@H](CCN2CCCCC2c2coc3cccc-3c2)CC1

HCID178478713

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)C1CCC(C(=O)N[C@H]2CC[C@H](CCN3CCCCC3c3coc4cccc-4c3)CC2)CC1

HCID178440970

未命名化合物

PROCEDURE

实验过程

The title compound, off-white solid (77 mg, 63%), MS (ISP) m/z=493.4 [(M+H)+], mp 199° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 4-tert-butyl-cyclohexanecarboxylic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1d4c56f2d3444edf910c8d448c57b156
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08921397B2
来源说明: uspto-grants-2014_12

反应 SMILES

Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[C:27]([CH:31]1[CH2:36][CH2:35][CH:34]([C:37](O)=[O:38])[CH2:33][CH2:32]1)([CH3:30])([CH3:29])[CH3:28]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:37]([CH:34]3[CH2:35][CH2:36][CH:31]([C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:32][CH2:33]3)=[O:38])[CH2:24][CH2:25]2)=[CH:4]1