4-Cyclopropylbenzoic acid → HCID 178523638, compound

HRID 1409941Notes

Reaction equation

HRID 1409941 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[CH:27]1([C:30]2[CH:38]=[CH:37][C:33]([C:34](O)=[O:35])=[CH:32][CH:31]=2)[CH2:29][CH2:28]1>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:34](=[O:35])[C:33]3[CH:37]=[CH:38][C:30]([CH:27]4[CH2:29][CH2:28]4)=[CH:31][CH:32]=3)[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 2820644-Cyclopropylbenzoic acidHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178523638HCID 178523638, compound

Procedure

The title compound, light yellow solid (85 mg, 72%), MS (ISP) m/z=471.4 [(M+H)+], mp 199° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 4-cyclopropyl-benzoic acid.

Sources & evidence

ORD record
ord-b76e40bad9e64cac950bb73387bf5ae4
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

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