4-(Trifluoromethyl)piperidine-1-carbonyl chloride → 6-Chlorobenzo[d]isoxazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate

HRID 1409988Notes

Reaction equation

HRID 1409988 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6]([OH:9])=[N:7][O:8][C:4]=2[CH:3]=1.[F:12][C:13]([F:24])([F:23])[CH:14]1[CH2:19][CH2:18][N:17]([C:20](Cl)=[O:21])[CH2:16][CH2:15]1>>[F:23][C:13]([F:12])([F:24])[CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:9][C:6]2[C:5]3[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][C:4]=3[O:8][N:7]=2)=[O:21])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 798870814-(Trifluoromethyl)piperidine-1-carbonyl chlorideHCID 178518989HCID 178518989, compound

Product 1

HCID 118577526-Chlorobenzo[d]isoxazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate

Procedure

In analogy to example 1,200 mg (1.18 mmol) of 6-chlorobenzo[d]isoxazol-3-ol were reacted with 305 mg (1.41 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 229 mg (56%), M+H+: 349.05.

Sources & evidence

ORD record
ord-5a9899811901403280f4b4e14efd6544
Source dataset
uspto-grants-2014_12
Patent number
US08921404B2

Reaction notes

Loading…