HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)piperidine-1-carbonyl chloride → 6-Chlorobenzo[d]isoxazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)piperidine-1-carbonyl chloride | HCID 79887081 | — |
| Reactant | HCID 178518989 | HCID 178518989 | — |
| Product | 6-Chlorobenzo[d]isoxazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate | HCID 11857752 | — |
Reaction Steps
In analogy to example 1,200 mg (1.18 mmol) of 6-chlorobenzo[d]isoxazol-3-ol were reacted with 305 mg (1.41 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 229 mg (56%), M+H+: 349.05.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921404B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-5a9899811901403280f4b4e14efd6544 |
| Source note | uspto-grants-2014_12 |