反应详情

A solution of tert-butyl 1-(7-(5,6-dimethoxypyridin-2-ylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-ylcarbamate (260 mg, 0.549 mmol) in 20 mL of saturated HCl in dioxane was stirred at room temperature for 24 hours. The solvent was evaporated to give 5-(3-aminopyrrolidin-1-yl)-N-(5,6-dimethoxypyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-amine hydrochloride (283 mg, crude) as a yellow solid. It was used directly in the next step without further purification. LC-MS: 187.6 [M/2+H]+, 374.0 [M+H]+, tR=1.18 min.

1. customThe solvent was evaporated