4-Bromophenacyl bromide → HCID 67113812, compound

HRID 1410177Notes

Reaction equation

HRID 1410177 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][NH2:17]>C(OCC)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][NH:17][CH2:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[O:13][CH3:12])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 812922-Methoxybenzylamine

Product 1

HCID 67113812HCID 67113812, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 500 mg (1.8 mmol) 2-bromo-1-(4-bromophenyl)ethanone and 520 mg (3.8 mmol) 2-methoxybenzylamine in 100 mL diethyl ether was stirred for 2 hr at room temperature. The resulting precipitate was then filtered, and the filtrate was combined with 1 M isopropanolic HCl and diluted with diethyl ether. The precipitate thus obtained was filtered and used in the subsequent step without further purification.

Workup

  1. filtrationThe resulting precipitate was then filtered
  2. additiondiluted with diethyl ether
  3. customThe precipitate thus obtained
  4. filtrationwas filtered
  5. customused in the subsequent step without further purification

Sources & evidence

ORD record
ord-fa6058405f644cc09917f0a10bcbed43
Source dataset
uspto-grants-2014_12
Patent number
US08921406B2

Reaction notes

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