Methanol → HCID 178513874, compound

HRID 1410178Notes

Reaction equation

HRID 1410178 reaction equation
BrCC([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=O.[C:14]([NH:17][C:18]([NH2:20])=N)(=O)[CH3:15].C[OH:22].[C:23](#[N:25])[CH3:24]>>[N+:11]([C:8]1[CH:7]=[CH:6][C:5]([C:14]2[N:17]=[C:18]([CH2:24][C:23]([NH2:25])=[O:22])[NH:20][CH:15]=2)=[CH:10][CH:9]=1)([O-:13])=[O:12]

Participants

5

Reactant 4

HCID 887MethanolHCID 6342AcetonitrileHCID 668402-Bromo-4'-nitroacetophenoneHCID 178475102HCID 178475102, compound

Product 1

HCID 178513874HCID 178513874, compound

Procedure

A solution of 5.0 g (20.5 mmol) 2-bromo-1-(4-nitrophenyl)ethanone and 5.0 g (49.5 mmol) acetylguanidine in 70 mL acetonitrile was stirred for 4 hr at 40° C. and for an additional 72 hr at room temperature. The resulting precipitate was suctioned off in a mixture with methanol, refiltered, and dried. The solid (0.7 g) thus obtained was used without further purification.

Workup

  1. customdried

Sources & evidence

ORD record
ord-d165f5a29a23451f8e2c90e387fb1cda
Source dataset
uspto-grants-2014_12
Patent number
US08921406B2

Reaction notes

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