Tetrahydrofuran → HCID 67230022, compound

HRID 1410192Notes

Reaction equation

HRID 1410192 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:19]=1[NH:20][CH3:21])[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][CH:11]=1)=[O:8])([O-])=O.C1COCC1>CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:19]=1[NH:20][CH3:21])[C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([Br:16])=[CH:14][CH:15]=1)=[O:8]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 7406921HCID 7406921, compound

Product 1

HCID 67230022HCID 67230022, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3-Nitro-N-(4-bromophenyl)-4-methylaminobenzamide (120 mg, 0.34 mmol), 10 ml THF, 10 ml MeOH and 30 mg 5%-Pt-on-carbon was stirred for 4 h under a hydrogen atmosphere (3.5 bar). The catalyst was removed by filtration and the mixture was concentrated and used in the next step without further purification.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe mixture was concentrated
  3. customused in the next step without further purification

Sources & evidence

ORD record
ord-6bcec334eb1f4c9099e025f4351ea38b
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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