HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfate → Ethyl 2-(2,2-difluoroethoxy)-4-methylamino-5-amino-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate | HCID 59529798 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 2-(2,2-difluoroethoxy)-4-methylamino-5-amino-benzoate | HCID 59529827 | — |
Reaction Steps
A mixture of ethyl 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoate (2.0 g; 6.57 mmol), Ra—Ni (1.0 g) and THF (100 mL) was stirred under H2-atmosphere (8 atm) over night at rt. Na2SO4 was added and the mixture was stirred another 30 min under H2-atmosphere. The mixture was filtered through celite and the sub-title compound was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921405B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-10d66185acac4a51a85727526940d1d6 |
| Source note | uspto-grants-2014_12 |