HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 59529874, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| Reactant | Ethyl 4-amino-2-fluoro-5-nitrobenzoate | HCID 59529828 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59529874 | HCID 59529874 | — |
Reaction Steps
The sub-title compound was prepared in accordance with Example 59 (f) using ethyl 4-amino-2-fluoro-5-nitrobenzoate (4.80 g; 21.0 mmol), 2,2-difluoroethanol (1.73 g; 21.0 mmol), sodium hydride (0.841 g; 60%; 21.0 mmol), THF (100 mL) and DMF (50 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921405B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3be220bdb2224afd9dfeecae16938a48 |
| Source note | uspto-grants-2014_12 |