Tetrahydrofuran → HCID 59529874, compound

HRID 1410231Notes

Reaction equation

HRID 1410231 reaction equation
[NH2:1][C:2]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4](F)[CH:3]=1.[F:17][CH:18]([F:21])[CH2:19][OH:20].[H-].[Na+].C1COCC1>CN(C=O)C>[NH2:1][C:2]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]([O:20][CH2:19][CH:18]([F:21])[F:17])[CH:3]=1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 1361872,2-Difluoroethan-1-olHCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoate

Product 1

HCID 59529874HCID 59529874, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The sub-title compound was prepared in accordance with Example 59 (f) using ethyl 4-amino-2-fluoro-5-nitrobenzoate (4.80 g; 21.0 mmol), 2,2-difluoroethanol (1.73 g; 21.0 mmol), sodium hydride (0.841 g; 60%; 21.0 mmol), THF (100 mL) and DMF (50 mL).

Sources & evidence

ORD record
ord-3be220bdb2224afd9dfeecae16938a48
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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