HCID 59529874, compound → HCID 59529892, compound

HRID 1410232Notes

Reaction equation

HRID 1410232 reaction equation
[NH2:1][C:2]1[C:12]([N+:13]([O-])=O)=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]([O:16][CH2:17][CH:18]([F:20])[F:19])[CH:3]=1>[Ni].C1COCC1>[NH2:1][C:2]1[C:12]([NH2:13])=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]([O:16][CH2:17][CH:18]([F:19])[F:20])[CH:3]=1

Participants

4

Reactant 1

HCID 59529874HCID 59529874, compound

Product 1

HCID 59529892HCID 59529892, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The sub-title compound was prepared in accordance with Example 59 (g) using ethyl 4-amino-2-(2,2-difluoroethoxy)-5-nitrobenzoate (1.00 g; 3.44 mmol), Ra—Ni (1.0 g) and THF (50 mL). The sub-title compound was used in the next step without further purification.

Workup

  1. customThe sub-title compound was used in the next step without further purification

Sources & evidence

ORD record
ord-3f1ae87a8d834b43b8e8ac4c9eb3d7a4
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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