Nitric Acid → HCID 59529860, compound

HRID 1410254Notes

Reaction equation

HRID 1410254 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1.OS(O)(=O)=O.[N+:16]([O-])([OH:18])=[O:17]>>[Cl:1][C:2]1[C:9]([N+:16]([O-:18])=[O:17])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 59529860HCID 59529860, compound

Conditions

Temperature
1.5 °C

Procedure

A mixture of 4-chloro-2-fluorobenzonitrile (4.62 g; 29.7 mmol) in cone. H2SO4 (42 mL) was treated dropwise with cone. HNO3 (3.9 mL) at 1-2° C. After stirring at 1-2° C. for 2 h the mixture was poured into ice and filtered to give the sub-title compound. Yield: 5.18 g (87%).

Workup

  1. customat 1-2° C
  2. additionwas poured into ice
  3. filtrationfiltered

Sources & evidence

ORD record
ord-421a8b23a4c345c6bd301bf873a25e6a
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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