HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1410254Generated: November 2, 2026
Nitric Acid → 4-Chloro-2-fluoro-5-nitrobenzonitrile
https://huagongshe.com/reaction/1410254
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Chloro-2-fluorobenzonitrile | HCID 93655 | — |
| Product | 4-Chloro-2-fluoro-5-nitrobenzonitrile | HCID 59529860 | — |
Reaction Steps
A mixture of 4-chloro-2-fluorobenzonitrile (4.62 g; 29.7 mmol) in cone. H2SO4 (42 mL) was treated dropwise with cone. HNO3 (3.9 mL) at 1-2° C. After stirring at 1-2° C. for 2 h the mixture was poured into ice and filtered to give the sub-title compound. Yield: 5.18 g (87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08921405B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-421a8b23a4c345c6bd301bf873a25e6a |
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| Source note | uspto-grants-2014_12 |
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