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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1410263Generated: October 31, 2026

4-Amino-2-methoxy-5-nitrobenzoic acid → HCID 178493230, compound

https://huagongshe.com/reaction/1410263

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Amino-2-methoxy-5-nitrobenzoic acidHCID 101016—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
ReactantDichloromethane ethanolHCID 21584144—
ReactantHCID 178511531HCID 178511531—
SolventDimethylformamideHCID 6228—
ProductHCID 178493230HCID 178493230—

Reaction Steps

The sub-title compound was prepared from 2-methoxy-4-amino-5-nitro benzoic acid and trans-4-trifluoromethyl-cyclohexylamine with TBTU and TEA in DMF in analogy to example 3e._Yield: quantitative; TLC: silica gel, DCM/EtOH 9:1, Rf=0.68.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08921405B2
Source datasetuspto-grants-2014_12
ORD IDord-ad3b5a80e71b4055b0b02bfc67d59ed3
Source noteuspto-grants-2014_12