Ammonia → HCID 178507678, compound

HRID 1410269Notes

Reaction equation

HRID 1410269 reaction equation
[NH3:1].[N+:2]([C:5]1[C:6](F)=[CH:7][C:8]([Cl:24])=[C:9]([CH:23]=1)[C:10]([NH:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([C:19]([F:22])([F:21])[F:20])[CH2:15][CH2:14]1)=[O:11])([O-:4])=[O:3].C1COCC1>O>[N+:2]([C:5]1[C:6]([NH2:1])=[CH:7][C:8]([Cl:24])=[C:9]([CH:23]=1)[C:10]([NH:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([C:19]([F:22])([F:21])[F:20])[CH2:15][CH2:14]1)=[O:11])([O-:4])=[O:3]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 178523752HCID 178523752, compound

Product 1

HCID 178507678HCID 178507678, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Conc. ammonia (0.8 ml) was added portionwise at −10° C. to a mixture of 5-nitro-2-chloro-4-fluoro-N-(trans-4-trifluoromethyl-cyclohex-1-yl)-benzamide (0.20 g, 0.54 mmol) and 10 ml THF and it was stirred overnight at room temperature. Water was added and the mixture was conc. i.vac. The residue was triturated with water and filtered. The filter cake was washed with water and dried to obtain the crude subtitle compound (MS m/z: 366 [M+H]+).

Workup

  1. customThe residue was triturated with water
  2. filtrationfiltered
  3. washThe filter cake was washed with water
  4. customdried

Sources & evidence

ORD record
ord-1b5fb931083b47e59c05a3c2150864c8
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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