反应详情

温度

55 °C

1 part by weight of dronedarone hydrochloride and 3.0 parts by weight of Povidone PVP K-30 were weighted and 12 parts by weight of dichloromethane were added into, and then stirred until the solution became clarified. The solution was transferred to a vacuum oven and maintained at 55° C., then dried under reduced pressure for 48 h and the dry mass was crushed with a 100 mesh sieve and thereby the solid dispersion of dronedarone was obtained.

1. customdried under reduced pressure for 48 h
2. customthe dry mass was crushed with a 100 mesh sieve