Dronedarone Hydrochloride → Dronedarone

HRID 1410282Notes

Reaction equation

HRID 1410282 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[O:13][C:12]2[CH:11]=[CH:10][C:9]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:8][C:7]=2[C:6]=1[C:19]([C:21]1[CH:22]=[CH:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][N:31]([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:32][CH2:33][CH2:34][CH3:35])=[CH:25][CH:26]=1)=[O:20].Cl>ClCCl>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[O:13][C:12]2[CH:11]=[CH:10][C:9]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:8][C:7]=2[C:6]=1[C:19]([C:21]1[CH:22]=[CH:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][N:31]([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:32][CH2:33][CH2:34][CH3:35])=[CH:25][CH:26]=1)=[O:20]

Participants

3

Reactant 1

HCID 219025Dronedarone Hydrochloride

Product 1

HCID 208898Dronedarone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
55 °C

Procedure

1 part by weight of dronedarone hydrochloride and 3.0 parts by weight of Povidone PVP K-30 were weighted and 12 parts by weight of dichloromethane were added into, and then stirred until the solution became clarified. The solution was transferred to a vacuum oven and maintained at 55° C., then dried under reduced pressure for 48 h and the dry mass was crushed with a 100 mesh sieve and thereby the solid dispersion of dronedarone was obtained.

Workup

  1. customdried under reduced pressure for 48 h
  2. customthe dry mass was crushed with a 100 mesh sieve

Sources & evidence

ORD record
ord-743924d2163145b186de702d30ca80d9
Source dataset
uspto-grants-2014_12
Patent number
US08921416B2

Reaction notes

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