反应详情

温度

65 °C

To a solution of 2-Bromo-5-chloro-4-(4-ethoxybenzyl)phenol (7, 55 mmol) in acetone (180 mL) were added potassium carbonate (15.2 g, 110 mmol) and allyl bromide (7 mL, 83 mmol) and heated at 65° C. for 3 h. The insoluble material was removed by filter and the filtrate was evaporated under reduced pressure. The crude residue was purified on Biotage® purification apparatus (silica gel, 3 to 10% ethyl acetate in hexanes) to yield the title compound (21 g, 52 mmol, 95%) as colorless oil.

1. customThe insoluble material was removed
2. filtrationby filter
3. customthe filtrate was evaporated under reduced pressure
4. customThe crude residue was purified on Biotage® purification apparatus (silica gel, 3 to 10% ethyl acetate in hexanes)