HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178478817, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178454180 | HCID 178454180 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178478817 | HCID 178478817 | — |
Reaction Steps
Hydrochloric acid (1 M) in acetic acid (380 L) was slowly added at ≦22° C. to a suspension of Boc-Arg-Pro-OBzl.HCl (95.00 kg; Hexagon Labs Inc., USA) in acetic acid (190 L) and THF (19 L). The completion of cleavage (after about 1 hour) was monitored by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921517B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-d498d2bd227941148cc75fb4903aff34 |
| Source note | uspto-grants-2014_12 |