Hydrochloric Acid → HCID 178478817, compound

HRID 1410325Notes

Reaction equation

HRID 1410325 reaction equation
[ClH:1].[NH:2](C(OC(C)(C)C)=O)[C@H:3]([C:11]([N:13]1[CH2:27][CH2:26][CH2:25][C@H:14]1[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])=[O:12])[CH2:4][CH2:5][CH2:6][NH:7][C:8](=[NH:10])[NH2:9].Cl>C(O)(=O)C.C1COCC1>[NH2:2][C@H:3]([C:11]([N:13]1[CH2:27][CH2:26][CH2:25][C@H:14]1[C:15]([O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:16])=[O:12])[CH2:4][CH2:5][CH2:6][NH:7][C:8](=[NH:9])[NH2:10].[ClH:1].[ClH:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178454180HCID 178454180, compound

Product 1

HCID 178478817HCID 178478817, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

Hydrochloric acid (1 M) in acetic acid (380 L) was slowly added at ≦22° C. to a suspension of Boc-Arg-Pro-OBzl.HCl (95.00 kg; Hexagon Labs Inc., USA) in acetic acid (190 L) and THF (19 L). The completion of cleavage (after about 1 hour) was monitored by HPLC.

Workup

  1. customThe completion of cleavage (after about 1 hour)

Sources & evidence

ORD record
ord-d498d2bd227941148cc75fb4903aff34
Source dataset
uspto-grants-2014_12
Patent number
US08921517B2

Reaction notes

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