(2E)-3-(3-Fluorophenyl)-2-propenoic acid → 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3-fluorocinnamoyl)-piperidin-4-yl]-acetamide

Participants

Reaction Steps

The title compound was prepared from the product of Example 1, step J (0.50 mmol), trans-3-fluorocinnamic acid, by the method of Example 1, step K, giving the title compound as a white solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C30H35FN4O2: 503 (M+H). Found: 503

Provenance & Evidence