3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLIC ACID → HCID 67772854, compound

HRID 1410536Notes

Reaction equation

HRID 1410536 reaction equation
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1.[O:29]1[C:34]2[CH:35]=[C:36](/[CH:39]=[CH:40]/[C:41](O)=[O:42])[CH:37]=[CH:38][C:33]=2[O:32][CH2:31][CH2:30]1>>[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:24][CH2:25][N:26]([C:41](=[O:42])/[CH:40]=[CH:39]/[C:36]4[CH:37]=[CH:38][C:33]5[O:32][CH2:31][CH2:30][O:29][C:34]=5[CH:35]=4)[CH2:27][CH2:28]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1

Participants

3

Reactant 2

HCID 61738403-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLIC ACIDHCID 677751942-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride

Product 1

HCID 67772854HCID 67772854, compound

Procedure

The title compound was prepared from the product of Example 1, step J, and trans-3-(2,3-dihydro-1,4-benzodioxin-7-yl)prop-2-enoic acid, by the method of Example 1, step K, giving a solid that was mostly the more polar cyclohexyl diastereomers by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C32H38N4O4: 543 (M+H). Found: 543

Workup

  1. customgiving a solid

Sources & evidence

ORD record
ord-f0deaf86f8af43f29f57188b09cccd66
Source dataset
uspto-grants-2014_12
Patent number
US08921559B2

Reaction notes

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