HCID 60005268, compound → HCID 57344302, compound

HRID 1410539Notes

Reaction equation

HRID 1410539 reaction equation
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1.[CH3:29][C:30]1([CH3:44])[CH2:34][C:33]2[CH:35]=[C:36](/[CH:39]=[CH:40]/[C:41](O)=[O:42])[CH:37]=[CH:38][C:32]=2[O:31]1>>[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([CH:23]3[CH2:24][CH2:25][N:26]([C:41](=[O:42])/[CH:40]=[CH:39]/[C:36]4[CH:37]=[CH:38][C:32]5[O:31][C:30]([CH3:29])([CH3:44])[CH2:34][C:33]=5[CH:35]=4)[CH2:27][CH2:28]3)[C:20]([NH2:22])=[O:21])[CH2:14][CH2:13]2)=[CH:4]1

Participants

3

Reactant 2

HCID 60005268HCID 60005268, compoundHCID 677751942-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochloride

Product 1

HCID 57344302HCID 57344302, compound

Procedure

The title compound was prepared from the product of Example 1, step J, and (2E)-3-(2,2-dimethyl-2,3-dihydro-1-benzofuran-5-yl)prop-2-enoic acid, by the method of Example 1, step K, giving a yellow solid that was a mixture of cyclohexyl diastereomers by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C33H40N4O3: 541 (M+H). Found: 541

Workup

  1. customgiving a yellow solid
  2. additiona mixture of cyclohexyl diastereomers by LCMS

Sources & evidence

ORD record
ord-2e2c86b71a0c47ac8deca7f6a9fb5eda
Source dataset
uspto-grants-2014_12
Patent number
US08921559B2

Reaction notes

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