反应详情

The title compound was prepared from 4-(6-methoxypyridin-3-yl)cyclohexanone (prepared from commercially available 4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexanone according to the general procedure shown in scheme 5), 2-amino-2-(1-tert-butoxycarbonyl-piperidin-4-yl)-acetamide (from Example 1, step G), and trans-3,4,5-trifluorocinnamic acid, by the methods of Example 1, steps H to K, giving a pale yellow solid as a mixture of cyclohexyl diastereomers.

1. customby the methods of Example 1, steps H to K, giving a pale yellow solid
2. additionas a mixture of cyclohexyl diastereomers