3,4,5-Trifluorocinnamic acid → 2-[4-(6-Methoxypyridin-3-yl)cyclohexyl]amino-2-[1-(trans-3,4,5-trifluorocinnamoyl)-piperidin-4-yl]-acetamide

HRID 1410542노트

반응식

HRID 1410542 반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.OC1(C2C=NC(OC)=CC=2)CCC(=O)CC1.[NH2:32][CH:33]([CH:37]1[CH2:42][CH2:41][N:40]([C:43]([O:45]C(C)(C)C)=O)[CH2:39][CH2:38]1)[C:34]([NH2:36])=[O:35].[F:50][C:51]1[CH:52]=[C:53]([CH:59]=[C:60]([F:63])[C:61]=1[F:62])/[CH:54]=[CH:55]/C(O)=O>>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][CH:12]([NH:32][CH:33]([CH:37]3[CH2:38][CH2:39][N:40]([C:43](=[O:45])/[CH:55]=[CH:54]/[C:53]4[CH:59]=[C:60]([F:63])[C:61]([F:62])=[C:51]([F:50])[CH:52]=4)[CH2:41][CH2:42]3)[C:34]([NH2:36])=[O:35])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 4

HCID 57087793,4,5-Trifluorocinnamic acidHCID 529879954-Hydroxy-4-(6-methoxypyridin-3-yl)cyclohexan-1-oneHCID 674788684-(6-Methoxypyridin-3-yl)cyclohexanoneHCID 677733632-Amino-2-(1-tert-butoxycarbonyl-piperidin-4-yl)-acetamide

생성물 1

HCID 573443152-[4-(6-Methoxypyridin-3-yl)cyclohexyl]amino-2-[1-(trans-3,4,5-trifluorocinnamoyl)-piperidin-4-yl]-acetamide

실험 절차

The title compound was prepared from 4-(6-methoxypyridin-3-yl)cyclohexanone (prepared from commercially available 4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexanone according to the general procedure shown in scheme 5), 2-amino-2-(1-tert-butoxycarbonyl-piperidin-4-yl)-acetamide (from Example 1, step G), and trans-3,4,5-trifluorocinnamic acid, by the methods of Example 1, steps H to K, giving a pale yellow solid as a mixture of cyclohexyl diastereomers.

후처리

  1. customby the methods of Example 1, steps H to K, giving a pale yellow solid
  2. additionas a mixture of cyclohexyl diastereomers

출처 및 근거

ORD 기록
ord-3a6a75171c2743bc963a630a0ab9d813
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921559B2

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