Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4,5-Trifluorocinnamic acid → 2-[4-(6-Methoxypyridin-3-yl)cyclohexyl]amino-2-[1-(trans-3,4,5-trifluorocinnamoyl)-piperidin-4-yl]-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4,5-Trifluorocinnamic acid | HCID 5708779 | — |
| 반응물 | 4-Hydroxy-4-(6-methoxypyridin-3-YL)cyclohexanone | HCID 52987995 | — |
| 반응물 | 4-(6-Methoxypyridin-3-yl)cyclohexanone | HCID 67478868 | — |
| 반응물 | 2-Amino-2-(1-tert-butoxycarbonyl-piperidin-4-yl)-acetamide | HCID 67773363 | — |
| 생성물 | 2-[4-(6-Methoxypyridin-3-yl)cyclohexyl]amino-2-[1-(trans-3,4,5-trifluorocinnamoyl)-piperidin-4-yl]-acetamide | HCID 57344315 | — |
반응 단계
The title compound was prepared from 4-(6-methoxypyridin-3-yl)cyclohexanone (prepared from commercially available 4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexanone according to the general procedure shown in scheme 5), 2-amino-2-(1-tert-butoxycarbonyl-piperidin-4-yl)-acetamide (from Example 1, step G), and trans-3,4,5-trifluorocinnamic acid, by the methods of Example 1, steps H to K, giving a pale yellow solid as a mixture of cyclohexyl diastereomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08921559B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-3a6a75171c2743bc963a630a0ab9d813 |
| 출처 메모 | uspto-grants-2014_12 |