Trifluoroacetic acid → L-Pyrrolysine

HRID 1411114노트

반응식

HRID 1411114 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:8]([O:10]C(C)(C)C)=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)[C:33]2C=CC=C[C:32]=2N=N1.C[N:50]1[CH2:55][CH2:54][O:53][CH2:52][CH2:51]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:52](=[O:53])[C@@H:51]1[N:50]=[CH:55][CH2:54][C@H:32]1[CH3:33]

참가 물질

6

반응물 4

HCID 6422Trifluoroacetic acidHCID 79724-MethylmorpholineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 10470194(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate

생성물 1

HCID 5460671L-Pyrrolysine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Step a) Boc-Lys-OtBu, BOP, NMM, CH2Cl2, RT, 48 hrs; Step b) TFA, RT, 1 hr, ˜100%.

출처 및 근거

ORD 기록
ord-2a17360854154b49b3a2f19b8996bb04
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921571B2

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