Hydrochloric Acid → HCID 86676524, compound

HRID 1411118Notes

Reaction equation

C(OC([NH:8][C@@H:9]([CH2:17][CH2:18][CH2:19][CH2:20][CH:21](C(OC)=O)[C:22]([CH:24]1[CH2:28][S:27]C(C)(C)[N:25]1C=O)=[O:23])[C:10]([O:12]C(C)(C)C)=[O:11])=O)(C)(C)C.[ClH:37]>>[ClH:37].[ClH:37].[NH2:8][C@@H:9]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22](=[O:23])[CH:24]([NH2:25])[CH2:28][SH:27])[C:10]([OH:12])=[O:11]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86676525HCID 86676525, compound

Product 1

HCID 86676524HCID 86676524, compound

Procedure

A solution of ketone 31 (401 mg, 0.76 mmol) in 4M HCl (6 mL) was refluxed for 2 hrs. The reaction mixture was cooled to room temperature and evaporated in vacuo to give the title compound 32 as a yellow oil that was used in subsequent biochemical studies without any further purification.

Workup

customevaporated in vacuo

Sources & evidence

ORD record: ord-b8d4683827844c079efa253d993f2912
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921571B2

Reaction notes

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