Azetidine hydrochloride → HCID 90449660, compound

HRID 1411304Notes

Reaction equation

[CH3:1][NH:2][C:3]([N:5]1[CH2:9][CH2:8][C:7]2([C:17]3[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][CH2:19][CH2:20][C:21](OCC)=[O:22])[CH:16]=3)[N:11]([C:26](=[O:35])[NH:27][C:28]3[CH:33]=[N:32][C:31]([CH3:34])=[CH:30][N:29]=3)[CH2:10]2)[CH2:6]1)=[O:4].Cl.[NH:37]1[CH2:40][CH2:39][CH2:38]1>>[N:37]1([C:21](=[O:22])[CH2:20][CH2:19][CH2:18][C:15]2[CH:16]=[C:17]3[C:7]4([CH2:8][CH2:9][N:5]([C:3]([NH:2][CH3:1])=[O:4])[CH2:6]4)[CH2:10][N:11]([C:26]([NH:27][C:28]4[CH:33]=[N:32][C:31]([CH3:34])=[CH:30][N:29]=4)=[O:35])[C:12]3=[CH:13][CH:14]=2)[CH2:40][CH2:39][CH2:38]1

Participants

Reactant 2

HCID 12308726Azetidine hydrochloride

HCID 90449992HCID 90449992, compound

Product 1

HCID 90449660HCID 90449660, compound

Procedure

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Examples 29 and 85, with the exceptions that the ethyl 4-(1′-(methylcarbamoyl)-1-((5-methylpyrazin-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidin]-5-yl)butanoate obtained in Example 420 was used instead of 2-((2-(1′-acetyl-5-bromospiro[indoline-3,3′-pyrrolidin]-1-ylcarboxamido)thiazol-5-yl)thio)acetate, and that azetidine hydrochloride was used instead of dimethylamine hydrochloride.

Workup

customThe captioned compound was obtained in the form of a white solid

Sources & evidence

ORD record: ord-1f6818ff65a144b789b8ceb3e241f77c
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921576B2

Reaction notes

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