Ammonia methanol → HCID 90449951, compound

HRID 1411320Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][N:12]([C:15]4[C:18](=O)[C:17](=[O:20])[C:16]=4[O:21]CC)[CH2:11]3)[CH2:9][N:8]([C:24]([NH:26][C:27]3[S:28][C:29]([Cl:32])=[CH:30][N:31]=3)=[O:25])[C:5]2=[CH:6][CH:7]=1.[CH3:33][NH2:34].O1CCCC1.N.CO>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][N:12]([C:15]4[C:16](=[O:21])[C:17](=[O:20])[C:18]=4[NH:34][CH3:33])[CH2:11]3)[CH2:9][N:8]([C:24]([NH:26][C:27]3[S:28][C:29]([Cl:32])=[CH:30][N:31]=3)=[O:25])[C:5]2=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 21705897Ammonia methanol

HCID 66615946Methylamine tetrahydrofuran

HCID 90449566HCID 90449566, compound

Product 1

HCID 90449951HCID 90449951, compound

Procedure

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 45, with the exceptions that the 5-chloro-N-(5-chlorothiazol-2-yl)-1′-(2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide obtained in Example 450 was used instead of ethyl 2-(5-chloro-1-((5-chlorothiazol-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidin]-1′-yl)-2-oxoacetate, and that a solution of methylamine-tetrahydrofuran was used instead of a saturated solution of ammonia-methanol.

Workup

customThe captioned compound was obtained in the form of a white solid

Sources & evidence

ORD record: ord-42426f7d28c14b64bff206f1516e5ef1
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921576B2

Reaction notes

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