Ammonia methanol → HCID 90449951, compound

Participants

Reaction Steps

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 45, with the exceptions that the 5-chloro-N-(5-chlorothiazol-2-yl)-1′-(2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide obtained in Example 450 was used instead of ethyl 2-(5-chloro-1-((5-chlorothiazol-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidin]-1′-yl)-2-oxoacetate, and that a solution of methylamine-tetrahydrofuran was used instead of a saturated solution of ammonia-methanol.

Provenance & Evidence