Phenacyl bromide → 6-Chloro-2-oxo-1-(2-oxo-2-phenyl-ethyl)-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

HRID 141284Notes

Reaction equation

HRID 141284 reaction equation
[Br:28][CH2:29][C:30](=[O:31])[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[Cl:1][c:2]1[cH:3][c:4]2[c:5]([N:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[c:23]4[s:24][cH:25][cH:26][cH:27]4)[CH2:19][CH2:20]3)[c:6]([C:13]#[N:14])[c:7](=[O:12])[nH:8][c:9]2[n:10][cH:11]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([N:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[c:23]4[s:24][cH:25][cH:26][cH:27]4)[CH2:19][CH2:20]3)[c:6]([C:13]#[N:14])[c:7](=[O:12])[n:8]([CH2:29][C:30](=[O:31])[c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[c:9]2[n:10][cH:11]1

Participants

3

Reactant 2

HCID 6259Phenacyl bromideHCID 692183766-Chloro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

Product 1

HCID 113069076-Chloro-2-oxo-1-(2-oxo-2-phenyl-ethyl)-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

Sources & evidence

ORD record
ord-be87c6efb9e3401a933c4ce44bdfe0eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…