Hydrochloric Acid → HCID 178494463, compound

HRID 1412995Notes

Reaction equation

HRID 1412995 reaction equation
[CH3:1][O:2][C:3]([NH:5][C@H:6]([C:10]([N:12]1[CH2:16][CH:15]([CH2:17][O:18][CH3:19])[CH2:14][CH:13]1[C:20]1[NH:24][C:23]2[C:25]3[C:30]([CH:31]=[CH:32][C:22]=2[N:21]=1)=[CH:29][C:28]1[C:33]2[C:38]([CH2:39][O:40][C:27]=1[CH:26]=3)=[CH:37][C:36]([C:41]1[NH:45][C:44]([CH:46]3[CH2:50][CH:49]([CH3:51])[CH2:48][N:47]3C(OC(C)(C)C)=O)=[N:43][CH:42]=1)=[CH:35][CH:34]=2)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4].Cl>C(O)C>[CH3:1][O:2][C:3](=[O:4])[NH:5][CH:6]([CH:7]([CH3:9])[CH3:8])[C:10]([N:12]1[CH2:16][CH:15]([CH2:17][O:18][CH3:19])[CH2:14][CH:13]1[C:20]1[NH:24][C:23]2[C:25]3[C:30]([CH:31]=[CH:32][C:22]=2[N:21]=1)=[CH:29][C:28]1[C:33]2[C:38]([CH2:39][O:40][C:27]=1[CH:26]=3)=[CH:37][C:36]([C:41]1[NH:45][C:44]([CH:46]3[CH2:50][CH:49]([CH3:51])[CH2:48][NH:47]3)=[N:43][CH:42]=1)=[CH:35][CH:34]=2)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178494461HCID 178494461, compound

Product 1

HCID 178494463HCID 178494463, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

tert-butyl 2-[5-(2-{1-[N-(methoxycarbonyl)valyl]-4-(methoxymethyl)pyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carboxylate (50 mg, 0.063 mmol) was treated with 2 mL 1.25N HCl in ethanol and heated at 60° C. for 2 h, then it was concentrated under reduced pressure and pumped dry under high vacuum and used directly in the next step.

Workup

  1. concentrationit was concentrated under reduced pressure
  2. custompumped dry under high vacuum

Sources & evidence

ORD record
ord-f6257207ea944a7b869f12a3d838bd6c
Source dataset
uspto-grants-2014_12
Patent number
US08921341B2

Reaction notes

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