1-(2,3-Dihydro-8-hydroxy-1,4-benzodioxin-5-yl)ethan-1-one → HCID 136335638, compound

HRID 1413074Notes

Reaction equation

HRID 1413074 reaction equation
[OH:1][C:2]1[C:11]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[C:5]([C:12](=O)[CH3:13])=[CH:4][CH:3]=1.Cl.[NH2:16][OH:17]>N1C=CC=CC=1.C(O)C>[OH:1][C:2]1[C:11]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[C:5]([C:12](=[N:16][OH:17])[CH3:13])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 803371-(2,3-Dihydro-8-hydroxy-1,4-benzodioxin-5-yl)ethan-1-oneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 136335638HCID 136335638, compoundYield 57.4%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1049PyridineSolvent

Procedure

A solution of 19.4 g (0.1 mole) of 5-hydroxyl 8-acetyl-1,4-benzodioxane (VIIi) and 10.4 g (0.15 mole) of hydroxylamine hydrochloride in 50 ml of pyridine and 50 ml of ethanol was brought to reflux for 7 hours. Then, the solvents were evaporated and the residue crystallized in water. 12 g of product were obtained.

Workup

  1. temperatureto reflux for 7 hours
  2. customThen, the solvents were evaporated
  3. customthe residue crystallized in water

Sources & evidence

ORD record
ord-0914686245c24263a59e9f4481e1efbc
Source dataset
uspto-grants-1981_02
Patent number
US04248788

Reaction notes

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