Propionyl chloride → HCID 20293163, compound

HRID 1413077Notes

Reaction equation

HRID 1413077 reaction equation
[CH2:1]([O:8][C:9]1[C:18]2[O:17][CH2:16][CH2:15][O:14][C:13]=2[C:12]([NH2:19])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20](Cl)(=[O:23])[CH2:21][CH3:22]>C(Cl)(Cl)Cl.C(N(CC)CC)C>[CH2:1]([O:8][C:9]1[C:18]2[O:17][CH2:16][CH2:15][O:14][C:13]=2[C:12]([NH:19][C:20](=[O:23])[CH2:21][CH3:22])=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 62324Propionyl chlorideHCID 13020422HCID 13020422, compound

Product 1

HCID 20293163HCID 20293163, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8471TriethylamineSolvent

Procedure

To a solution of 30 g of 5-benzyloxy-8-amino-1,4-benzodioxane (XX); code number 760 727, in 250 ml of chloroform and 21.3 ml of triethylamine, cooled to 0° C., 12.1 cm3 of propionyl chloride were slowly added. Then, it was stirred for 17 hours, washed with a solution of diluted hydrochloric acid, with water, with an aqueous solution of sodium bicarbonate, then with water, the organic phase was evaporated and the residue recrystallized in ethyl acetate.

Workup

  1. washwashed with a solution of diluted hydrochloric acid, with water, with an aqueous solution of sodium bicarbonate
  2. customwith water, the organic phase was evaporated
  3. customthe residue recrystallized in ethyl acetate

Sources & evidence

ORD record
ord-b2f3a427bbe245ce97e3cc219783cedd
Source dataset
uspto-grants-1981_02
Patent number
US04248788

Reaction notes

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