Sodium Bicarbonate → HCID 20549196, compound

HRID 1413086Notes

Reaction equation

HRID 1413086 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].C(=O)(O)[O-].[Na+].[CH2:14]([C:16]1([C:24](Cl)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[CH3:15]>O.CCOCC>[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH:7][C:24]([C:16]1([CH2:14][CH3:15])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)=[O:25])[CH3:3]

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 2723640Glycine ethyl ester, hydrochlorideHCID 20549184HCID 20549184, compound

Product 1

HCID 20549196HCID 20549196, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

Glycine ethyl ester hydrochloride (0.04 mole) and sodium bicarbonate (0.08 mole) were dissolved in water (50 ml.). 1-Ethylcyclooctanecarbonyl chloride (1 g. 0.04 mole) in ether (20 ml.) was then added with stirring. The ether layer was separated, dried (MgSO4) and concentrated. The residue was recrystallised from 40°-60° petroleum ether to give N-(1-ethylcyclooctanecarbonyl) glycine ethyl ester mp. 65°-7°

Workup

  1. customThe ether layer was separated
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated
  4. customThe residue was recrystallised from 40°-60° petroleum ether

Sources & evidence

ORD record
ord-bd841a57b2054d6a94dc3ba6f85ef603
Source dataset
uspto-grants-1981_02
Patent number
US04248859

Reaction notes

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