2-Amino-2-methyl-1-propanol → HCID 86737466, compound

HRID 1413090Notes

Reaction equation

HRID 1413090 reaction equation
[CH3:1][C:2]1([CH3:13])[CH2:8][CH2:7][CH2:6][CH:5]([CH3:9])[CH:4]([C:10](Cl)=[O:11])[CH2:3]1.[NH2:14]C(C)(C)CO>C(Cl)Cl>[CH3:1][C:2]1([CH3:13])[CH2:8][CH2:7][CH2:6][CH:5]([CH3:9])[CH:4]([C:10]([NH2:14])=[O:11])[CH2:3]1

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 20549179HCID 20549179, compound

Product 1

HCID 86737466HCID 86737466, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

3,3,7-Trimethylcycloheptanecarbonyl chloride, prepared from the product of Part A by the method of Example 26 Part B, (0.5 g. 0.0025 mole) in 10 ml methylene dichloride was added to a stirred solution of 2-amino-2,2-dimethylethanol (0.5 g) in 50 ml methylene dichloride. After 3 hours the solution was washed with 2 N HCl, then with NaHCO3 solution and then dried (MgSO4). Removal of the solvent left an oil which was distilled to yield N-1',1'-dimethyl-2'-hydroxyethyl)-3,3,7-trimethylcycloheptanecarboxamide, bp. 135°/0.015 mm.

Workup

  1. washAfter 3 hours the solution was washed with 2 N HCl
  2. dry with materialwith NaHCO3 solution and then dried (MgSO4)
  3. customRemoval of the solvent
  4. waitleft an oil which
  5. distillationwas distilled

Sources & evidence

ORD record
ord-83490d8bcc6b446f8647dfdebfdc16d0
Source dataset
uspto-grants-1981_02
Patent number
US04248859

Reaction notes

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