HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1413197Generated: October 26, 2026
5-Fluorouracil → 1,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione
https://huagongshe.com/reaction/1413197
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | 2,3-Dihydrofuran | HCID 70934 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione | HCID 124956 | — |
Reaction Steps
In 20.8 ml of pyridine were dissolved 5.2 g (40 m mol) of 5-fluorouracil and 9.8 g (140 m mol) of 2,3-dihydrofuran. The solution was heated at about 160° C. in a closed tubular reactor under agitation for 5 hours. The resultant reaction mixture was treated similarly to Example 7 to give the above mentioned-compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04249006 |
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| Source dataset | uspto-grants-1981_02 |
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| ORD ID | ord-1ea1786e9d7141798e9e1650d0b1a6f5 |
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| Source note | uspto-grants-1981_02 |
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