Nitric Acid → 2-(1,1-Dimethylethyl)-4-methyl-1H-imidazole-5-carboxaldehyde

HRID 1413263Notes

Reaction equation

[C:1]([C:5]1[NH:6][C:7]([CH3:12])=[C:8]([CH2:10][OH:11])[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[N+]([O-])(O)=O>>[C:1]([C:5]1[NH:6][C:7]([CH3:12])=[C:8]([CH:10]=[O:11])[N:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 944Nitric Acid

HCID 12493281HCID 12493281, compound

Product 1

HCID 124932852-(1,1-Dimethylethyl)-4-methyl-1H-imidazole-5-carboxaldehyde

Procedure

A 19.76 gm. portion of 2-tert-butyl-5-methyl-4-imidazolemethanol and 16.5 ml. of concentrated HNO3 are reacted as described in Example 25 giving the desired product, m.p. 196°-198° C.

Sources & evidence

ORD record: ord-7bd7d981330b4d09b79531b636f5013d
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE030511

Reaction notes

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