Hydroxylamine, O-ethyl- → HCID 178474725, compound

HRID 1413318Notes

Reaction equation

HRID 1413318 reaction equation
[C:1]([CH:5]1[C:10](=[O:11])[CH2:9][CH:8]([CH2:12][CH2:13][S:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:7][C:6]1=[O:22])(=O)[CH2:2][CH3:3].[CH2:23]([O:25][NH2:26])[CH3:24]>CO>[CH2:23]([O:25][NH:26][C:1](=[C:5]1[C:10](=[O:11])[CH2:9][CH:8]([CH2:12][CH2:13][S:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:7][C:6]1=[O:22])[CH2:2][CH3:3])[CH3:24]

Participants

4

Reactant 2

HCID 69357Hydroxylamine, O-ethyl-HCID 20291504HCID 20291504, compound

Product 1

HCID 178474725HCID 178474725, compoundYield 55.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.6 g of 2-propionyl-5-[2-(4-chlorophenylthio)ethyl]cyclohexane-1,3-dione was allowed to react with 0.8 g of ethoxyamine at room temperature for 16 hours in 60 ml of methanol. After completion of the reaction, the resulting reaction solution was treated as in Example 1 to obtain oily product. Purification of the oily product by column chromatography gave 1 g of the desired compound as colorless oily material.

Workup

  1. customAfter completion of the reaction
  2. customthe resulting reaction solution
  3. additionwas treated as in Example 1
  4. customto obtain oily product
  5. customPurification of the oily product by column chromatography

Sources & evidence

ORD record
ord-cfd3efc305294d46a20e09694ce36f16
Source dataset
uspto-grants-1981_02
Patent number
US04249937

Reaction notes

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