Sodium Hydroxide → HCID 20291458, compound

HRID 1413325Notes

Reaction equation

HRID 1413325 reaction equation
[C:1]1([CH:7]2[NH:11][CH2:10][CH:9]([CH2:12][O:13][CH3:14])[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]([CH2:19][CH2:20][C:21](Cl)=[O:22])([O:17][CH3:18])=[O:16].[OH-].[Na+]>C1C=CC=CC=1>[C:1]1([C:7]2([C:21](=[O:22])[CH2:20][CH2:19][C:15]([O:17][CH3:18])=[O:16])[NH:11][CH2:10][CH:9]([CH2:12][O:13][CH3:14])[O:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 20291461HCID 20291461, compound

Product 1

HCID 20291458HCID 20291458, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 19.3 milliliters of 25 percent w/v, 2-phenyl-5-methoxymethyl oxazolidine solution in 50 milliliters of benzene with 3.8 grams of 3-carbomethoxyproprionyl chloride was added 2.0 grams of 50% sodium hydroxide. After the reaction was complete the mixture was washed with water, separated, dried and the organic solvent removed in vacuo. There was obtained 6.8 grams of the title compound, nD30 1.4913. Analytical data supports the structure.

Workup

  1. washwas washed with water
  2. customseparated
  3. customdried
  4. customthe organic solvent removed in vacuo

Sources & evidence

ORD record
ord-785123b5cc8746baaa160eb999dd281d
Source dataset
uspto-grants-1981_02
Patent number
US04249931

Reaction notes

Loading…