3-Aminobenzenesulfonic acid → 4-Phenyl-2-(3-sulfophenylamino)-thiazole

HRID 1413332Notes

Reaction equation

HRID 1413332 reaction equation
[CH2:1]([S:10][C:11]#[N:12])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([OH:23])(=[O:22])=[O:21])[CH:15]=1>[Cl-].[Zn+2].[Cl-].O>[C:4]1([C:2]2[N:12]=[C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([OH:23])(=[O:21])=[O:22])[CH:15]=3)[S:10][CH:1]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 84743-Aminobenzenesulfonic acidHCID 219693Phenacyl thiocyanate

Product 1

HCID 202918054-Phenyl-2-(3-sulfophenylamino)-thiazole

Reagents, catalysts & solvents 2

HCID 3007855ZincchlorideCatalystHCID 962WaterSolvent

Procedure

132 parts of phenacyl thiocyanate, 38 parts of zinc chloride and 129 parts of 1-aminobenzene-3-sulfonic acid are together stirred with 750 parts of water for 20 hours at the boil. After the mixture has cooled, the product is filtered off and dried.

Workup

  1. temperatureAfter the mixture has cooled
  2. filtrationthe product is filtered off
  3. customdried

Sources & evidence

ORD record
ord-e475d43585464d9f8a762862e4edc5fc
Source dataset
uspto-grants-1981_02
Patent number
US04250090

Reaction notes

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