Dimethylamine → HCID 20291811, compound

HRID 1413369Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH3:26])[C:5]2[N:11]3[C:12]([CH2:15]Br)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][C:20]([S:23][CH3:24])=[CH:19][CH:18]=3)[C:6]=2[CH:25]=1.[CH3:27][NH:28][CH3:29].[I-].[Na+]>>[CH3:27][N:28]([CH2:15][C:12]1[N:11]2[C:5]3[C:4]([CH3:26])=[CH:3][C:2]([CH3:1])=[CH:25][C:6]=3[C:7]([C:17]3[CH:22]=[CH:21][C:20]([S:23][CH3:24])=[CH:19][CH:18]=3)=[N:8][CH2:9][C:10]2=[N:14][N:13]=1)[CH3:29]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 5238Sodium Iodide

HCID 20291819HCID 20291819, compound

Product 1

HCID 20291811HCID 20291811, compound

Procedure

In the manner given in Example 1, 8,10-dimethyl-1-(bromomethyl)-6-[p-(methylthio)phenyl]-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine was reacted with dimethylamine in the presence of sodium iodide to give 1-[(dimethylamino)methyl]-8,10-dimethyl-6-[p-(methylthio)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-b7f8d96e207745f1b7b1dd3e21592517
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250094

Reaction notes

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