Sodium Iodide → HCID 20291815, compound

HRID 1413372Notes

Reaction equation

HRID 1413372 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH:15](Cl)[CH2:16][CH3:17])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:6]=2[CH:26]=1.[CH2:27]([NH:30][CH2:31][CH2:32][CH3:33])[CH2:28][CH3:29].[I-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH:15]([N:30]([CH2:31][CH2:32][CH3:33])[CH2:27][CH2:28][CH3:29])[CH2:16][CH3:17])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:6]=2[CH:26]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 8902DipropylamineHCID 20291855HCID 20291855, compound

Product 1

HCID 20291815HCID 20291815, compound

Procedure

In a manner given in Example 1, 8-chloro-1-(α-chloropropyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine was reacted with dipropylamine in the presence of sodium iodide to give 8-chloro-1-[α-(dipropylamino)propyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-811949e9ebf448c58ca58dab778781ee
Source dataset
uspto-grants-1981_02
Patent number
US04250094

Reaction notes

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