Sodium Iodide → HCID 20291809, compound

HRID 1413374Notes

Reaction equation

HRID 1413374 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16]Cl)=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Br:24])[C:7]=2[CH:25]=1.[CH2:28]([NH:31][CH2:32][CH2:33][CH3:34])[CH2:29][CH3:30].[I-].[Na+]>>[CH2:28]([N:31]([CH2:16][C:13]1[N:12]2[C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:27])([F:26])[F:1])=[CH:25][C:7]=3[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Br:24])=[N:9][CH2:10][C:11]2=[N:15][N:14]=1)[CH2:32][CH2:33][CH3:34])[CH2:29][CH3:30]

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 8902DipropylamineHCID 57259787HCID 57259787, compound

Product 1

HCID 20291809HCID 20291809, compound

Procedure

In the manner given in Example 1, 8-trifluoromethyl-1-(chloromethyl)-6-(o-bromophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine was reacted with dipropylamine in the presence of sodium iodide to give 1-[(dipropylamino)methyl]-8-trifluoromethyl-6-(o-bromophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-4a267c09c8de42aaad4b4bdc174d9a1b
Source dataset
uspto-grants-1981_02
Patent number
US04250094

Reaction notes

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