Dimethylamine → HCID 20291861, compound

HRID 1413375Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:8]2[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([S:25][CH3:26])[CH:20]=3)=[N:10][CH2:11][C:12]3[N:13]([C:14]([CH2:17]Cl)=[N:15][N:16]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH3:27][NH:28][CH3:29].[I-].[Na+]>>[CH3:27][N:28]([CH2:17][C:14]1[N:13]2[C:7]3[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([S:25][CH3:26])[CH:20]=3)=[N:10][CH2:11][C:12]2=[N:16][N:15]=1)[CH3:29]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 5238Sodium Iodide

HCID 20291858HCID 20291858, compound

Product 1

HCID 20291861HCID 20291861, compound

Procedure

In the manner given in Example 1, 7-methoxy-1-(chloromethyl)-6-[m-(methylthio)phenyl]-4H-s-triazolo-[4,3-a][1,4]benzodiazepine was reacted with dimethylamine in the presence of sodium iodide to give 1-[(dimethylamino)methyl]-7-methoxy-6-[m-(methylthio)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-8e6abc8a96ec45919deff08db112ff03
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250094

Reaction notes

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