Dimethylamine → HCID 20291814, compound

HRID 1413376Notes

Reaction equation

[CH2:1]([S:4][C:5]1[CH:32]=[CH:31][C:8]2[C:9]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH3:28])=[CH:23][C:22]=3[CH2:29][CH3:30])=[N:10][CH2:11][C:12]3[N:13]([C:14]([CH:17](Cl)[CH2:18][CH3:19])=[N:15][N:16]=3)[C:7]=2[CH:6]=1)[CH2:2][CH3:3].[CH3:33][NH:34][CH3:35].[I-].[Na+]>>[CH3:33][N:34]([CH3:35])[CH:17]([C:14]1[N:13]2[C:7]3[CH:6]=[C:5]([S:4][CH2:1][CH2:2][CH3:3])[CH:32]=[CH:31][C:8]=3[C:9]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH3:28])=[CH:23][C:22]=3[CH2:29][CH3:30])=[N:10][CH2:11][C:12]2=[N:16][N:15]=1)[CH2:18][CH3:19]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 5238Sodium Iodide

HCID 20291853HCID 20291853, compound

Product 1

HCID 20291814HCID 20291814, compound

Procedure

In the manner given in Example 1, 9-(propylthio)-1-(α-chloropropyl)-6-(2,4-diethylphenyl)-4H-s-triazolo[4,3-a]-[1,4]-benzodiazepine was reacted with dimethylamine in the presence of sodium iodide to give 1-[α-(dimethylamino)propyl]-9-(propylthio)-6-(2,4-diethylphenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-43e4a548a2ba4209ae54561915167473
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250094

Reaction notes

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