Dimethylamine → HCID 20291818, compound

HRID 1413378Notes

Reaction equation

[CH2:1]([C:3]1[C:8]2[C:9]([C:21]3[CH:26]=[C:25]([Cl:27])[CH:24]=[C:23]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])[CH:22]=3)=[N:10][CH2:11][C:12]3[N:13]([C:14]([CH:17](Br)[CH2:18][CH3:19])=[N:15][N:16]=3)[C:7]=2[C:6]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:5][CH:4]=1)[CH3:2].[CH3:37][NH:38][CH3:39].[I-].[Na+]>>[CH2:1]([C:3]1[C:8]2[C:9]([C:21]3[CH:26]=[C:25]([Cl:27])[CH:24]=[C:23]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])[CH:22]=3)=[N:10][CH2:11][C:12]3[N:13]([C:14]([CH:17]([N:38]([CH3:39])[CH3:37])[CH2:18][CH3:19])=[N:15][N:16]=3)[C:7]=2[C:6]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:5][CH:4]=1)[CH3:2]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 5238Sodium Iodide

HCID 20291827HCID 20291827, compound

Product 1

HCID 20291818HCID 20291818, compound

Procedure

In the manner given in Example 1, 7-ethyl-10-methylsulfonyl-1-(α-bromopropyl)-6-(3-ethylsulfonyl-5-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine was reacted with dimethylamine in the presence of sodium iodide to give 7-ethyl-1-[α-(dimethylamino)propyl]-10-methylsulfonyl-6-(3-ethylsulfonyl-5-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-535831399f32469191521b79ccb92bc4
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250094

Reaction notes

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