Methanol → HCID 86737479, compound

HRID 1413404Notes

Reaction equation

HRID 1413404 reaction equation
C(O[C:9]([N:11](C)[C@H:12]([C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([C:24]([NH:26][C@H:27]([P:29](=[O:32])([OH:31])[OH:30])[CH3:28])=[O:25])[CH3:23])=[O:20])[CH3:18])=[O:15])[CH3:13])=O)C1C=CC=CC=1.CO>C(O)C>[CH3:9][NH:11][C@H:12]([C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([C:24]([NH:26][C@H:27]([P:29](=[O:30])([OH:32])[OH:31])[CH3:28])=[O:25])[CH3:23])=[O:20])[CH3:18])=[O:15])[CH3:13]

Participants

4

Reactant 2

HCID 887MethanolHCID 53910628HCID 53910628, compound

Product 1

HCID 86737479HCID 86737479, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner analogous to that described in Example 19(B)(ii), from (1R)-1-[(N-benzyloxycarbonyl-N-methyl-L-alanyl-L-alanyl-L-alanyl)amino]-ethylphosphonic acid, but carrying out the hydrogenation in aqueous ethanol instead of aqueous methanol, there was obtained (1R)-1-(N-methyl-L-alanyl-L-alanyl-L-alanylamino)-ethylphosphonic acid of melting point 318°-320° C. (decomposition); [α]D20 =-121°; [α]36520 =-418° (c=0.5% in water).

Sources & evidence

ORD record
ord-5bc4046fdae24e4b969c59548df7d306
Source dataset
uspto-grants-1981_02
Patent number
US04250085

Reaction notes

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