反应详情

温度

-5 °C

N-Benzylglycine hydrochloride was taken up in 2-N sodium hydroxide and the mixture was stirred at -5° C. while 4-N sodium hydroxide and benzyl chloroformate were simultaneously added dropwise. The mixture was stirred in the cold for 2 hours and then stirred at room temperature for 0.5 hour. Excess benzyl chloroformate was removed by extraction with ether. The aqueous layer was cooled to -5° C. and acidified with concentrated hydrochloric acid. The mixture was stirred in the cold for 1 hour, then brought to room temperature and extracted 4 times with diethyl ether. The diethyl ether extracts were back-washed with water, filtered and then dried over anhydrous sulphate and again filtered. Evaporation gave N-benzyl-N-benzyloxycarbonyl-glycine in the form of an oil.

1. additionwere simultaneously added dropwise
2. stirringstirred at room temperature for 0.5 hour
3. customExcess benzyl chloroformate was removed by extraction with ether
4. stirringThe mixture was stirred in the cold for 1 hour
5. custombrought to room temperature
6. extractionextracted 4 times with diethyl ether
7. washThe diethyl ether extracts were back-washed with water
8. filtrationfiltered
9. dry with materialdried over anhydrous sulphate
10. filtrationagain filtered
11. customEvaporation