HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 3-Iodo-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methyl [6-(phenylsulfanyl)imidazo[1,2-a]pyridin-2-yl]carbamate | HCID 12414300 | — |
| Reactant | Potassium Iodate | HCID 23665710 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Iodo-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine | HCID 54288948 | — |
Reaction Steps
A suspension of 2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine (600 mg., 2 mmoles), iodine (420 mg., 3.2 mmoles) and potassium iodate (180 mg., 0.8 mmole) in 60% aqueous acetic acid (50 ml.) containing 2 ml. of concentrated sulfuric acid is stirred at room temperature for 48 hours. The solution is diluted with ice water and the pH adjusted to 8 with aqueous sodium bicarbonate. The reaction mixture is extracted with dichloromethane and the dried extracts are evaporated in vacuo to yield 3-iodo-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04250174 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-72989007dde14c72a0a9172cbaf46e2e |
| Source note | uspto-grants-1981_02 |